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KMID : 0931320060060020145
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대한상부위장관.헬리코박터학회지
2006 Volume.6 No. 2 p.145 ~ p.149
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A Case of Activated Crohn’s Disease with Acute Duodenal Ulcer Bleeding after NSAID Use
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Song Hyun-Joo
Shim Ki-Nam
Ryu Kum-Hei
Yeom Hye-Jung
Kim Seong-Eun
Kim Tae-Hun
Jung Sung-Ae
Yoo Kwon
Moon Il-Hwan
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Abstract
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Crohn’s disease (CD) is a systemic granulomatous disease that may involve any part of the alimentary tract. CD is more common in the terminal ileum and right colon, but rare (only 0.5∼4.0%) in duodenum. Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce prostaglandin production by inhibiting the activation of cyclooxygenase enzyme and have usually been used for arthritis and arthralgia. Inhibition of prostaglandin synthesis not only contributes to the generation of ulcers in the upper gastrointestinal tract, but it can also exacerbate mucosal injury in the small intestine and colon and cause reactivation of quiescent CD. Herein, we report on a case of activated CD with acute massive duodenal ulcer bleeding after NSAID use, and we include a review of the relevant literatures. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2006;6:145-149)
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KEYWORD
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Crohn’s disease, Duodenal ulcer bleeding, Nonsteroidal anti-inflammatory drug
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